Development of oxidative stress in laboratory rats with alcohol intoxication

Introduction: the imbalance between formation of reactive oxygen species (ROS) and ability cells to neutralize them is characterized as oxidative stress occurs in almost any pathological condition. Reactions convert ethanol acetic acid are accompanied by an increase ROS production. Given prevalence alcohol abuse contribution development conditions, we formulated aim our work: assess impact chronic intoxication on mucous membranes digestive tract, liver, serum bone laboratory rats. Materials Methods: experiment was performed 2-month-old rats both sexes. The method alcoholization “semi-voluntary”. experimental groups were given with 5 % drinking water at beginning gradually increased 15 %. duration 108 days. Catalase activity (a marker antioxidant system) malonic dialdehyde content (an indicator degree lipid peroxidation) determined serum, jaw bone, mouth, stomach, small intestine, colon antioxidant-prooxidant index calculated from values ​​of these indicators. Results: prolonged consumption males females led a decrease catalase tissues tract 16.0 large intestinal 25.0 mucosa, and, conversely, jaws. membrane oral cavity liver 1.2–38.6 Chronic concentration gastrointestinal 20.3–96.6 %, – 20.4–33.3 tissue 44.8–58.7 balance antioxidants prooxidants most clearly reflects index. Alcohol contributed reduction 37.6–65.0 24.7 38.3 jaws 4.2–15.9 In cavity, this figure 6.0–10.0 Conclusions: According results study, induced developed greater extent lesser mouth bone. Female more resistant due consumption.